Our Approach
Unlocking Cell Regeneration to Combat Chronic Diseases
Metanoia Bio, a Los Angeles-based biotechnology company spun out from UCLA, is pioneering a novel approach to preventing and reversing chronic and age-related diseases. Our proprietary platform technology focuses on functional cell regeneration, a process that replaces old, damaged cells with healthy, fully functional ones.
This technology, licensed from Dr. Slavica Tudzarova's UCLA lab, utilizes a unique pharmacological approach to stimulate this natural cell renewal process. We currently target diseases like diabetes, diabetic retinopathy, pancreatic cancer, Alzheimer's disease, and heart failure.
Ensuring Human Translation:
To bridge the gap between research and real-world application, we leverage various tools and resources:
- Humanized transgenic mouse models: These models mimic human biology, allowing us to test our therapy's effectiveness in a relevant setting.
- Human pancreata from the nPOD collection: These samples provide valuable insights into human pancreatic function and disease states.
- Genomic analysis: By analyzing human single-cell RNA-sequencing data and spatial transcriptomics, we gain a deeper understanding of cell-specific processes in disease.
Our research has identified a key mechanism in the early stages of diabetes (prediabetes) where the body's natural "quality control" system, responsible for removing dysfunctional cells, becomes impaired. This leads to the accumulation of these harmful cells, contributing to disease progression.
Key Innovation:
Metanoia's approach differs from conventional medications that target specific pathways within malfunctioning cells. Instead, we harness an "evolutionary favored" mechanism, encouraging the natural selection of fit and healthy cells over dysfunctional ones. This offers a potentially more physiological and effective approach to disease management.
A World-Class Team:
We are backed by a team of international experts in science, business, technology, and medicine. Our advisory board comprises leading figures in the medical and scientific communities, providing invaluable guidance and expertise.
Dr. Tudzarova leads the scientific charge, collaborating with cutting-edge technologies both within UCLA and externally to advance our research and development programs.
Metanoia Bio represents a promising future in the fight against chronic diseases. By harnessing the power of functional cell regeneration, we aim to transform lives and offer hope for a healthier tomorrow.